Clemson is ranked third in the Associated Press Preseason Top 25.
The Tigers are aiming for their seventh consecutive trip to the College Football Playoff.
Alabama is No. 1 in AP preseason college football poll for fourth time in the past six seasons.
The Crimson Tide are the defending national champions. Alabama received 47 of 63 first-place votes from sports writers and broadcasters who vote in the poll presented by Regions Bank.
Oklahoma is No. 2 with six first-place votes, just ahead of Clemson who also received six first-place votes.
Ohio State and Georgia round out the top five. The Big Ten, SEC and Pac-12 conferences each have five teams in the Top 25. The ACC and Big 12 each have three.
1. Alabama (47)
2. Oklahoma (6)
3. Clemson (6)
4. Ohio State (1)
5. Georgia (3)
6. Texas A&M
7. Iowa State
8. Cincinnati
9. Notre Dame
10. North Carolina
11. Oregon
12. Wisconsin
13. Florida
14. Miami (FL)
15. USC
16. LSU
17. Indiana
18. Iowa
19. Penn State
20. Washington
21. Texas
22. Coastal Carolina
23. Louisiana
24. Utah
25. Arizona State